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Article

Hand2 elevates cardiomyocyte production during zebrafish heart development and regeneration.

Development (Cambridge, England) - 1 Aug 2014

Schindler Yocheved L, Garske Kristina M, Wang Jinhu, Firulli Beth A, Firulli Anthony B, Poss Kenneth D, Yelon Deborah

Abstract excerpt

Embryonic heart formation requires the production of an appropriate number of cardiomyocytes; likewise, cardiac regeneration following injury relies upon the recovery of lost cardiomyocytes. The basic helix-loop-helix (bHLH) transcription factor Hand2 has been implicated in promoting cardiomyocyte formation. It is unclear, however, whether Hand2 plays an instructive or permissive role during this process. Here,...

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Identifiers

PMID: 25038045
DOI: 10.1242/dev.106336
PMCID: PMC4197543

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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