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HAND factors regulate cardiac lineage commitment and differentiation from human pluripotent stem cells

5 Feb 2024

Abstract excerpt

BACKGROUND: Transcription factors HAND1 and HAND2 (HAND1/2) play significant roles in cardiac organogenesis. Abnormal expression and deficiency of HAND1/2 result in severe cardiac defects. However, the function and mechanism of HAND1/2 in regulating human early cardiac lineage commitment and differentiation are still unclear. METHODS: cells with flow cytometry. The expression of specific markers for heart fields...

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Share to Cardiac electrophysiology and arrhythmias
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PMID: 38317221
DOI: 10.1186/s13287-024-03649-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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