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Article

Hand2 ensures an appropriate environment for cardiac fusion by limiting Fibronectin function.

Development (Cambridge, England) - 1 Oct 2010

Garavito-Aguilar Zayra V, Riley Heather E, Yelon Deborah

Abstract excerpt

Heart formation requires the fusion of bilateral cardiomyocyte populations as they move towards the embryonic midline. The bHLH transcription factor Hand2 is essential for cardiac fusion; however, the effector genes that execute this function of Hand2 are unknown. Here, we provide in zebrafish the first evidence for a downstream component of the Hand2 pathway that mediates cardiac morphogenesis. Although hand2 is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20724450
DOI: 10.1242/dev.052225
PMCID: PMC2934734

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Hand2 ensures an appropriate environment for cardiac fusion by limiting Fibronectin function.PMID 20724450Read ↗

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