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Article

Hand2 function in second heart field progenitors is essential for cardiogenesis.

Developmental biology - 1 Mar 2011

Tsuchihashi Takatoshi, Maeda Jun, Shin Chong H, Ivey Kathryn N, Black Brian L, Olson Eric N, Yamagishi Hiroyuki, Srivastava Deepak

Abstract excerpt

Cardiogenesis involves the contributions of multiple progenitor pools, including mesoderm-derived cardiac progenitors known as the first and second heart fields. Disruption of genetic pathways regulating individual subsets of cardiac progenitors likely underlies many forms of human cardiac malfor...

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Identifiers

PMID: 21185281
DOI: 10.1016/j.ydbio.2010.12.023
PMCID: PMC3039109

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21185281-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Hand2 function in second heart field progenitors is essential for cardiogenesis.PMID 21185281Read ↗

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Hand2 ensures an appropriate environment for cardiac fusion by limiting Fibronectin function.Semantic proximity Read ↗

Cardiac Neural Crest Expression of Hand2 Regulates Outflow and Second Heart Field DevelopmentSemantic proximity Read ↗

The level of HAND1 controls the specification of multipotent cardiac and extraembryonic progenitorsSemantic proximity Read ↗

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Analysis of the Hand1 cell lineage reveals novel contributions to cardiovascular, neural crest, extra-embryonic, and lateral mesoderm derivatives.Semantic proximity Read ↗

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