Article
The Hand1 and Hand2 transcription factors regulate expansion of the embryonic cardiac ventricles in a gene dosage-dependent manner.
Development (Cambridge, England) - 1 Jan 2005
McFadden David G, Barbosa Ana C, Richardson James A, Schneider Michael D, Srivastava Deepak, Olson Eric N
Abstract excerpt
The basic helix-loop-helix transcription factors Hand1 and Hand2 display dynamic and spatially restricted expression patterns in the developing heart. Mice that lack Hand2 die at embryonic day 10.5 from right ventricular hypoplasia and vascular defects, whereas mice that lack Hand1 die at embryonic day 8.5 from placental and extra-embryonic abnormalities that preclude analysis of its potential role in later...
Topics
- Alleles
- Animals
- Basic Helix-Loop-Helix Transcription Factors
- Cell Differentiation
- Crosses, Genetic
- DNA-Binding Proteins
- Gene Deletion
- Gene Dosage
- Gene Expression Regulation, Developmental
- Genotype
- Heart
- Homeobox Protein Nkx-2.5
- Homeodomain Proteins