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Article

PDGFRA is a conserved HAND2 effector during early cardiac development.

Nature cardiovascular research - 1 Dec 2024

Xu Yanli, Gehlot Rupal, Capon Samuel J, Albu Marga, Gretz Jonas, Bloomekatz Joshua, Mattonet Kenny, Vucicevic Dubravka, Talyan Sweta, Kikhi Khrievono, Günther Stefan, Looso Mario, Firulli Beth A, Sanda Miloslav, Firulli Anthony B, Lacadie Scott Allen, Yelon Deborah, Stainier Didier Y R

Abstract excerpt

The basic helix-loop-helix transcription factor HAND2 has multiple roles during vertebrate organogenesis, including cardiogenesis. However, much remains to be uncovered about its mechanism of action. Here, we show the generation of several hand2 mutant alleles in zebrafish and demonstrate that dimerization-deficient mutants display the null phenotype but DNA-binding-deficient mutants do not. Rescue experiments...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptor, Platelet-Derived Growth Factor alpha

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Source

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Identifiers

PMID: 39658721
DOI: 10.1038/s44161-024-00574-1
PMCID: PMC11634778

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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