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Article

Hand2 Is an Essential Regulator for Two Notch-Dependent Functions within the Embryonic Endocardium

1 Dec 2014

Abstract excerpt

The basic-helix-loop-helix (bHLH) transcription factor Hand2 plays critical roles during cardiac morphogenesis via expression and function within myocardial, neural crest, and epicardial cell populations. Here, we show that Hand2 plays two essential Notch-dependent roles within the endocardium. Endocardial ablation of Hand2 results in failure to develop a patent tricuspid valve, intraventricular septum defects,...

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Identifiers

PMID: 25497097
DOI: 10.1016/j.celrep.2014.11.021

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