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Article

Hand factor ablation causes defective left ventricular chamber development and compromised adult cardiac function.

PLoS genetics - 1 Jul 2017

Vincentz Joshua W, Toolan Kevin P, Zhang Wenjun, Firulli Anthony B

Abstract excerpt

Coordinated cardiomyocyte growth, differentiation, and morphogenesis are essential for heart formation. We demonstrate that the bHLH transcription factors Hand1 and Hand2 play critical regulatory roles for left ventricle (LV) cardiomyocyte proliferation and morphogenesis. Using an LV-specific Cre allele (Hand1LV-Cre), we ablate Hand1-lineage cardiomyocytes, revealing that DTA-mediated cardiomyocyte death results...

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Share to Basic Helix-Loop-Helix Transcription Factors
Share to Cell Differentiation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Gene Expression Regulation, Developmental

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Share to Myocytes, Cardiac

Source

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Identifiers

PMID: 28732025
DOI: 10.1371/journal.pgen.1006922
PMCID: PMC5544250

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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