The level of HAND1 controls the specification of multipotent cardiac and extraembryonic progenitors

Abstract excerpt

<h4>Summary</h4> Diverse sets of progenitors contribute to the development of the embryonic heart, but the mechanisms of their specification have remained elusive. Here, using a human pluripotent stem cell (hPSC) model, we deciphered cardiac and non-cardiac lineage trajectories in differentiation and identified transcription factors underpinning cell specification, identity and function. We discovered a concentra...

Topics

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• Basic Helix-Loop-Helix Transcription Factors
• Cardiomyopathy and Myosin Studies
• Cardiovascular Function and Risk Factors
• Cell Survival
• Congenital heart defects research
• Gene Expression Profiling
• Gene Expression Regulation, Developmental
• Heart

Identifiers and source

Literature Corpus work

50019bc1-d6ef-5dd6-ba30-c1731c03ac88

DOI

10.1101/2024.08.15.607916