Article
Characterization of a putative spindle assembly checkpoint kinase Mps1, suggests its involvement in cell division, morphogenesis and oxidative stress tolerance in Candida albicans.
PloS one - 1 Jan 2014
Kamthan Mohan, Nalla Vijaya Kumar, Ruhela Deepa, Kamthan Ayushi, Maiti Protiti, Datta Asis
Abstract excerpt
In Saccharomyces cerevisiae MPS1 is one of the major protein kinase that governs the spindle checkpoint pathway. The S. cerevisiae structural homolog of opportunistic pathogen Candida albicans CaMPS1, is indispensable for the cell viability. The essentiality of Mps1 was confirmed by Homozygote Trisome test. To determine its biological function in this pathogen conditional mutant was generated through regulatable...
Topics
- Amino Acid Sequence
- Animals
- Candida albicans
- Cell Division
- Female
- Gene Order
- Genetic Vectors
- M Phase Cell Cycle Checkpoints
- Mice
- Molecular Sequence Data