Inducible gene deletion reveals essentiality of protein kinases and a septation initiation network in Candida albicans.

Abstract excerpt

Protein kinases are key components of many signaling pathways that regulate cellular activities, and some of them are indispensable for the viability of cells. We used inducible gene deletion to assess the importance of a set of putative essential protein kinases for growth and viability of the pathogenic yeast Candida albicans and to get clues about the functions of uncharacterized essential kinases. We found...

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