Article
Mitogen activated protein kinases SakA(HOG1) and MpkC collaborate for Aspergillus fumigatus virulence.
Molecular microbiology - 1 Jun 2016
Bruder Nascimento Ariane Cristina Mendes de Oliveira, Dos Reis Thaila Fernanda, de Castro Patrícia Alves, Hori Juliana I, Bom Vinícius Leite Pedro, de Assis Leandro José, Ramalho Leandra Naira Zambelli, Rocha Marina Campos, Malavazi Iran, Brown Neil Andrew, Valiante Vito, Brakhage Axel A, Hagiwara Daisuke, Goldman Gustavo H
Abstract excerpt
Here, we investigated which stress responses were influenced by the MpkC and SakA mitogen-activated protein kinases of the high-osmolarity glycerol (HOG) pathway in the fungal pathogen Aspergillus fumigatus. The ΔsakA and the double ΔmpkC ΔsakA mutants were more sensitive to osmotic and oxidative stresses, and to cell wall damaging agents. Both MpkC::GFP and SakA::GFP translocated to the nucleus upon osmotic...
Topics
- Animals
- Aspergillus fumigatus
- Biofilms
- Cell Wall
- Congo Red
- Fungal Proteins
- Gene Expression Regulation, Fungal
- Mice
- Mitogen-Activated Protein Kinases