Article

Mps1 expression is critical for chromosome orientation and segregation in yeast with high ploidy

2020-03-29

Abstract excerpt

In aneuploid cancer cells, the chromosome segregation apparatus is sensitive to increased chromosome number. The conserved protein kinase, Mps1, is a critical actor of this machinery, orienting the chromosomes properly on the spindle. Abnormally high levels of this kinase have been found in tumors with elevated chromosome number. However, it remains unclear, mechanistically, if and how cells with higher ploidy bec...

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Literature Corpus work: 3ee0feaf-361d-5e25-aadb-7d778d0f2f52
DOI: 10.1101/2020.03.26.006387

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