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The MPS1 Family of Protein Kinases

22 May 2012

Abstract excerpt

MPS1 protein kinases are found widely, but not ubiquitously, in eukaryotes. This family of potentially dual-specific protein kinases is among several that regulate a number of steps of mitosis. The most widely conserved MPS1 kinase functions involve activities at the kinetochore in both the chromosome attachment and the spindle checkpoint. MPS1 kinases also function at centrosomes. Beyond mitosis, MPS1 kinases...

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PMID: 22482908
DOI: 10.1146/annurev-biochem-061611-090435

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