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Article

Chemical genetics reveals a role for Mps1 kinase in kinetochore attachment during mitosis.

Current biology : CB - 26 Jan 2005

Jones Michele H, Huneycutt Brenda J, Pearson Chad G, Zhang Chao, Morgan Garry, Shokat Kevan, Bloom Kerry, Winey Mark

Abstract excerpt

Accurate chromosome segregation depends on proper assembly and function of the kinetochore and the mitotic spindle. In the budding yeast, Saccharomyces cerevisiae, the highly conserved protein kinase Mps1 has well-characterized roles in spindle pole body (SPB, yeast centrosome equivalent) duplication and the mitotic checkpoint. However, an additional role for Mps1 is suggested by phenotypes of MPS1 mutations that...

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PMID: 15668173
DOI: 10.1016/j.cub.2005.01.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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