Chemical genetics reveals a role for Mps1 kinase in kinetochore attachment during mitosis.

doi:10.1016/j.cub.2005.01.010

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Article

Chemical genetics reveals a role for Mps1 kinase in kinetochore attachment during mitosis.

Current biology : CB - 26 Jan 2005

Jones Michele H, Huneycutt Brenda J, Pearson Chad G, Zhang Chao, Morgan Garry, Shokat Kevan, Bloom Kerry, Winey Mark

Abstract excerpt

Accurate chromosome segregation depends on proper assembly and function of the kinetochore and the mitotic spindle. In the budding yeast, Saccharomyces cerevisiae, the highly conserved protein kinase Mps1 has well-characterized roles in spindle pole body (SPB, yeast centrosome equivalent) duplication and the mitotic checkpoint. However, an additional role for Mps1 is suggested by phenotypes of MPS1 mutations that...

Topics

Amino Acid Sequence
Blotting, Western
CDC28 Protein Kinase, S cerevisiae
Chromosome Segregation
Flow Cytometry
Fluorescent Antibody Technique
Kinetochores
Microscopy, Electron
Mitosis
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Protein Serine-Threonine Kinases

Protein-Tyrosine Kinases

Saccharomyces cerevisiae

Saccharomyces cerevisiae Proteins

Sequence Alignment

Spindle Apparatus

Source

Open in PubMed

Identifiers

PMID: 15668173
DOI: 10.1016/j.cub.2005.01.010

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-15668173-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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