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Article

The mitotic arrest in response to hypoxia and of polar bodies during early embryogenesis requires Drosophila Mps1.

Current biology : CB - 23 Nov 2004

Fischer Matthias G, Heeger Sebastian, Häcker Udo, Lehner Christian F

Abstract excerpt

Mps1 kinase plays an evolutionary conserved role in the mitotic spindle checkpoint. This system precludes anaphase onset until all chromosomes have successfully attached to spindle microtubules via their kinetochores. Mps1 overexpression in budding yeast is sufficient to trigger a mitotic arrest, which is dependent on the other mitotic checkpoint components, Bub1, Bub3, Mad1, Mad2, and Mad3. Therefore, Mps1 might...

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Source

Identifiers

PMID: 15556864
DOI: 10.1016/j.cub.2004.11.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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