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Article

Quercetin significantly inhibits the metabolism of caffeine, a substrate of cytochrome P450 1A2 unrelated to CYP1A21C (-2964G>A) and 1F (734C>A) gene polymorphisms.

BioMed research international - 1 Jan 2014

Xiao Jian, Huang Wei-Hua, Peng Jing-Bo, Tan Zhi-Rong, Ou-Yang Dong-Sheng, Hu Dong-Li, Zhang Wei, Chen Yao

Abstract excerpt

BACKGROUND: Quercetin is abundant in plants and human diets. Previous studies indicated that quercetin inhibited the activity of CYP1A2, and the combination of quercetin with the substrates of CYP1A2 might produce herb-drug interactions. This research aims to determine the effects of quercetin and the CYP1A2 gene polymorphisms, namely, CYP1A2*1C (-2964G>A) and *1F (734C>A), on the metabolism of caffeine. METHOD:...

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Identifiers

PMID: 25025048
DOI: 10.1155/2014/405071
PMCID: PMC4082882

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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