Flavonoids As CYP3A4 Inhibitors In Vitro

Abstract excerpt

Flavonoids, a diverse group of polyphenolic compounds found abundantly in fruits, vegetables, and beverages like tea and wine, offer a plethora of health benefits. However, their potential interaction with drug metabolism, particularly through inhibition of the cytochrome P450 3A4 enzyme, the most versatile and abundant enzyme in the liver. CYP3A4 is responsible for metabolizing approximately 50% of clinically pre...

Topics

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• Cytochrome P-450 Enzyme System
• Dietary Supplements
• Drug-Induced Hepatotoxicity and Protection
• Drug Transport and Resistance Mechanisms
• Magnoliopsida
• Pharmacogenetics and Drug Metabolism
• Phenotype
• Plant Extracts

Identifiers and source

Literature Corpus work

1640e503-4db1-5204-a2fd-e5212282bfd2

DOI

10.20944/preprints202401.0803.v1