Article

Evaluation of the Effect of Ritlecitinib on the Pharmacokinetics of Caffeine in Healthy Participants

2022-10-22

Abstract excerpt

<h4>Objective: </h4> This clinical study was conducted to evaluate the impact of ritlecitinib on the pharmacokinetics (PK) of caffeine, a cytochrome P450 1A2 (CYP1A2) substrate. <h4>Methods:</h4> In this single-center, single-arm, open-label, fixed-sequence study, healthy participants received a single 100-mg dose of caffeine on two separate occasions: on Day 1 of Period 1 as monotherapy and on Day 8 of Period 2 a...

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Literature Corpus work: ee1292bf-f256-51ef-94f8-5d839e0a85fb
DOI: 10.22541/au.166645623.32214629/v1

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