Article
New specific marker of cytochrome P450 1A2 activity.
Bulletin of experimental biology and medicine - 1 Apr 2011
Filimonova A A, Ziganshina L E, Ziganshin A U, Chichirov A A
Abstract excerpt
Various methods were proposed for phenotyping of patients by activity of cytochrome P450 1A2, each has some advantages and disadvantages. However, no reference parameters were developed for measuring CYP1A2 activity that could be used as a unified standard for phenotyping of patients. We propose a mathematic model of caffeine metabolism allowing calculation of rate constants for the formation of its primary...
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