Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The impact of genetic polymorphisms on CYP1A2 activity in humans: a systematic review and meta-analysis.

The pharmacogenomics journal - 1 Dec 2018

Koonrungsesomboon Nut, Khatsri Rapheephorn, Wongchompoo Penwisa, Teekachunhatean Supanimit

Abstract excerpt

A large interindividual variation in the activity of cytochrome P450 1A2 (CYP1A2) raises concern about therapeutic failure or toxicity when medical professionals prescribe drugs extensively metabolized by CYP1A2. To date, a number of studies have assessed the association between genetic polymorphisms and CYP1A2 activity; however, there are controversies as to the functional importance of CYP1A2 polymorphisms on...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caffeine
Share to Cytochrome P-450 CYP1A2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Homozygote

Share to Pharmacogenetics

Share to Pharmacogenomic Variants

Share to Smokers

Share to Smoking

Share to Substrate Specificity

Source

Identifiers

PMID: 29282363
DOI: 10.1038/s41397-017-0011-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The impact of genetic polymorphisms on CYP1A2 activity in humans: a systematic review and meta-analysis.PMID 29282363Read ↗

The G-113A polymorphism in CYP1A2 affects the caffeine metabolic ratio in a Chinese population.Semantic proximity Read ↗

Variability of caffeine metabolism by CYP1A2 polymorphism in different populationsSemantic proximity Read ↗

Genic-intergenic polymorphisms of CYP1A genes and their clinical impact.Semantic proximity Read ↗

Gender and ethnicity modify the association between the CYP1A2 rs762551 polymorphism and habitual coffee intake: evidence from a meta-analysis.Semantic proximity Read ↗

Induction of CYP1A2 by heavy coffee consumption is associated with the CYP1A2 -163C>A polymorphism.Semantic proximity Read ↗

Polymorphism of human cytochrome P450 enzymes and its clinical impact.Semantic proximity Read ↗

Influence of genetic polymorphisms, smoking, gender and age on CYP1A2 activity in a Turkish population.Semantic proximity Read ↗

Impact of smoking, smoking cessation, and genetic polymorphisms on CYP1A2 activity and inducibility.Semantic proximity Read ↗

Haplotypes in the 5'-untranslated region of the CYP1A2 gene are inversely associated with lung cancer risk but do not correlate with caffeine metabolism.Semantic proximity Read ↗

Polymorphisms in the cytochrome P450 CYP1A2 gene (CYP1A2) in colorectal cancer patients and controls: allele frequencies, linkage disequilibrium and influence on caffeine metabolism.Semantic proximity Read ↗

Insights into the substrate specificity, inhibitors, regulation, and polymorphisms and the clinical impact of human cytochrome P450 1A2.Semantic proximity Read ↗

Human cytochrome P4501A2.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.