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Article

The G-113A polymorphism in CYP1A2 affects the caffeine metabolic ratio in a Chinese population.

Clinical pharmacology and therapeutics - 1 Sept 2005

Chen Xiaoping, Wang Liqing, Zhi Lianteng, Zhou Gangqiao, Wang Haijian, Zhang Xiumei, Hao Bingtao, Zhu Yunping, Cheng Zeneng, He Fuchu

Abstract excerpt

OBJECTIVE: This study was designed to better understand genetic variation in the cytochrome P450 (CYP) gene CYP1A2 and its impact on CYP1A2 activity in Chinese subjects. METHODS: CYP1A2 genetic polymorphisms were screened by direct sequencing in 27 selected Chinese subjects. Plasma 1,7-dimethylxanthine/caffeine ratios 5 hours after a 100-mg caffeine administration, used as an index of CYP1A2 in vivo activity,...

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Source

Identifiers

PMID: 16153396
DOI: 10.1016/j.clpt.2005.05.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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