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Article

Validation of a high-performance liquid chromatography assay for quantification of caffeine and paraxanthine in human serum in the context of CYP1A2 phenotyping.

Biomedical chromatography : BMC - 1 Jun 1999

Koch J P, ten Tusscher G W, Koppe J G, Guchelaar H J

Abstract excerpt

In this study the validation of a reversed-phase high-performance liquid chromatography (HPLC) method, with UV-detection, for both caffeine and paraxanthine in human serum is described. This method is feasible for cytochrome P450 1A2 (CYP1A2) phenotyping, according to the results of a pilot study...

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Source

Identifiers

PMID: 10416066
DOI: 10.1002/(SICI)1099-0801(199906)13:4<309::AID-BMC881>3.0.CO;2-J

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-10416066-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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