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Article

Phenotypic polymorphism and gender-related differences of CYP1A2 activity in a Chinese population.

British journal of clinical pharmacology - 1 Feb 2000

Ou-Yang D S, Huang S L, Wang W, Xie H G, Xu Z H, Shu Y, Zhou H H

Abstract excerpt

AIMS: To investigate the distribution characteristics of CYP1A2 in a Chinese population, and to examine gender-related differences in CYP1A2 activity. METHODS: Two hundred and twenty-nine healthy subjects, 120 men and 109 women, were enrolled in this study. CYP1A2 activity was measured by plasma paraxanthine/caffeine (1,7X/1,3,7X) ratio 6 h after administration of 300 mg caffeine. The concentrations of...

Topics

Adolescent
Adult
Caffeine
China
Chromatography, High Pressure Liquid
Cytochrome P-450 CYP1A2
Data Interpretation, Statistical
Female
Humans
Male
Metabolic Clearance Rate

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Polymorphism, Genetic

Sex Factors

Theophylline

Source

Open in PubMed Open full text

Identifiers

PMID: 10671909
DOI: 10.1046/j.1365-2125.2000.00128.x
PMCID: PMC2014904

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