Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Simple and reliable CYP1A2 phenotyping by the paraxanthine/caffeine ratio in plasma and in saliva.

Pharmacogenetics - 1 Jun 1994

Fuhr U, Rost K L

Abstract excerpt

Several procedures to monitor CYP1A2 activity in vivo by the use of caffeine as a probe have been proposed. They comprise caffeine clearance, based on both plasma and saliva concentrations, urinary metabolite ratios, the 13C-caffeine breath test, and the paraxanthine/caffeine ratio in plasma. The latter method is fast, simple, economical and restricted to one sampling point. In this study, we retrospectively...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Caffeine
Share to Cytochrome P-450 Enzyme System

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Molecular Probes

Share to Oxidoreductases

Share to Phenotype

Share to Reference Values

Share to Saliva

Source

Identifiers

PMID: 7920690
DOI: 10.1097/00008571-199406000-00001

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Simple and reliable CYP1A2 phenotyping by the paraxanthine/caffeine ratio in plasma and in saliva.PMID 7920690Read ↗

Development and validation of a reversed-phase HPLC method for CYP1A2 phenotyping by use of a caffeine metabolite ratio in saliva.Semantic proximity Read ↗

Caffeine and paraxanthine HPLC assay for CYP1A2 phenotype assessment using saliva and plasma.Semantic proximity Read ↗

Salivary caffeine metabolic ratio in alcohol-dependent subjects.Semantic proximity Read ↗

Assessment of CYP1A2 activity in clinical practice: why, how, and when?Semantic proximity Read ↗

CYP1A2 in a smoking and a non-smoking population; correlation of urinary and salivary phenotypic ratios.Semantic proximity Read ↗

Analysis of caffeine and paraxanthine in human saliva with ultra-high-performance liquid chromatography for CYP1A2 phenotyping.Semantic proximity Read ↗

Paraxanthine/Caffeine Concentration Ratios in Hair: An Alternative for Plasma-Based Phenotyping of Cytochrome P450 1A2?Semantic proximity Read ↗

Caffeine metabolic ratios for the in vivo evaluation of CYP1A2, N-acetyltransferase 2, xanthine oxidase and CYP2A6 enzymatic activities.Semantic proximity Read ↗

Tacrine is not an ideal probe drug for measuring CYP1A2 activity in vivo.Semantic proximity Read ↗

Reproducibility of the nicotine metabolite ratio in cigarette smokers.Semantic proximity Read ↗

The basel cocktail for simultaneous phenotyping of human cytochrome P450 isoforms in plasma, saliva and dried blood spots.Semantic proximity Read ↗

Evaluation of caffeine as a test drug for CYP1A2, NAT2 and CYP2E1 phenotyping in man by in vivo versus in vitro correlations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.