Simple and reliable CYP1A2 phenotyping by the paraxanthine/caffeine ratio in plasma and in saliva.

doi:10.1097/00008571-199406000-00001

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Article

Simple and reliable CYP1A2 phenotyping by the paraxanthine/caffeine ratio in plasma and in saliva.

Pharmacogenetics - 1 Jun 1994

Fuhr U, Rost K L

Abstract excerpt

Several procedures to monitor CYP1A2 activity in vivo by the use of caffeine as a probe have been proposed. They comprise caffeine clearance, based on both plasma and saliva concentrations, urinary metabolite ratios, the 13C-caffeine breath test, and the paraxanthine/caffeine ratio in plasma. The...

Topics

Adult
Aged
Caffeine
Cytochrome P-450 CYP1A2
Cytochrome P-450 Enzyme System
Female
Humans
Male
Metabolic Clearance Rate
Middle Aged
Molecular Probes
Oxidoreductases
Phenotype
Reference Values
Retrospective Studies
Saliva
Theophylline

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