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Article

Serine phosphorylation on position 1033 of vinculin impacts cellular mechanics.

Biochemical and biophysical research communications - 25 Jul 2014

Auernheimer Vera, Goldmann Wolfgang H

Abstract excerpt

This study evaluates the influence of S1033 vinculin phosphorylation on the mechanical properties of cells. We demonstrate that MEFvcl KO cells transfected with the non-phosphorylatable eGFP-vinculin mutant S1033A are of lower stiffness compared to MEFvcl Rescue and phospho-mimicking mutant S1033D cells, which were of similar stiffness. Analogous, 2D traction microscopy indicates that MEFvcl Rescue and MEF mutant...

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Identifiers

PMID: 24996180
DOI: 10.1016/j.bbrc.2014.06.122

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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