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Article

The effects of increased extracellular deformation, pressure, and integrin phosphorylation on fibroblast migration.

The Journal of surgical research - 1 Sept 2009

Flanigan Thomas L, Craig David H, Gayer Christopher P, Basson Marc D

Abstract excerpt

Wound healing requires fibroblast migration. Increased pressure slows migration and ulcer healing. Pressure also induces beta1 integrin phosphorylation. We hypothesized that beta1 phosphorylation influences cell adhesion and migration. We compared the effects of increased pressure on the adhesion and motility of GD25 beta1-integrin null fibroblasts transfected with wild-type beta1A-integrin, S785A or TT788/9AA...

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Identifiers

PMID: 19555977
DOI: 10.1016/j.jss.2009.03.053
PMCID: PMC2730954

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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