Article

Intercellular adhesion stiffness moderates cell decoupling on stiff substrates

2019-10-13

Abstract excerpt

The interplay between cell-cell and cell-substrate interactions is complex yet necessary for the formation and well-functioning of tissues. The same mechanosensing mechanisms used by the cell to sense its extracellular matrix, also play a role in intercellular interactions. We used the discrete element method to develop a computational model of a deformable cell that includes subcellular components responsible for...

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Literature Corpus work: b864c2f0-93d7-5761-97ef-6b2c7acddb4c
DOI: 10.1101/802520

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