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Article

Vinculin E29R mutation changes cellular mechanics.

Biochemical and biophysical research communications - 26 Sept 2014

Auernheimer Vera, Goldmann Wolfgang H

Abstract excerpt

We investigated the effect of the point mutation E29R on vinculin under cell mechanical aspects. MEFvcl KO cells were transfected with intact eGFP-vinculin (rescue) or mutant E29R vinculin. Cellular stiffness and adhesion strength of mutant E29R vinculin were considerably higher compared to rescue and MEFvcl KO cells. 2D traction microscopy also indicated markedly higher strain energy in E29R mutant cells...

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Source

Identifiers

PMID: 25193699
DOI: 10.1016/j.bbrc.2014.08.133

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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