Article

A Phosphorylation Switch Governs KIF11’s Mechanical Output During Mitosis

2026-01-25

Abstract excerpt

The kinesin-5 motor protein KIF11 is crucial for mitotic spindle assembly, driving the separation of spindle poles through microtubule sliding. Src-family kinases phosphorylate KIF11 at multiple tyrosine residues within its motor domain, but the mechanistic consequences of these modifications remain unclear. Here, we dissect the role of phosphorylation at Y211 using phospho-mimetic (Y211E) and non-phosphorylatable...

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Literature Corpus work: ae497693-b2f6-544f-9227-a6edbe07bbfe
DOI: 10.64898/2026.01.23.700875

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