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Article

Differential expression of APE1 and APE2 in germinal centers promotes error-prone repair and A:T mutations during somatic hypermutation.

Proceedings of the National Academy of Sciences of the United States of America - 24 Jun 2014

Stavnezer Janet, Linehan Erin K, Thompson Mikayla R, Habboub Ghaith, Ucher Anna J, Kadungure Tatenda, Tsuchimoto Daisuke, Nakabeppu Yusaku, Schrader Carol E

Abstract excerpt

Somatic hypermutation (SHM) of antibody variable region genes is initiated in germinal center B cells during an immune response by activation-induced cytidine deaminase (AID), which converts cytosines to uracils. During accurate repair in nonmutating cells, uracil is excised by uracil DNA glycosylase (UNG), leaving abasic sites that are incised by AP endonuclease (APE) to create single-strand breaks, and the...

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Share to DNA-(Apurinic or Apyrimidinic Site) Lyase
Share to DNA Glycosylases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Germinal Center

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Share to Somatic Hypermutation, Immunoglobulin

Source

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Identifiers

PMID: 24927551
DOI: 10.1073/pnas.1405590111
PMCID: PMC4078814

Genes

UNG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Differential expression of APE1 and APE2 in germinal centers promotes error-prone repair and A:T mutations during somatic hypermutation.PMID 24927551Read ↗

APE2 Promotes AID-Dependent Somatic Hypermutation in Primary B Cell Cultures That Is Suppressed by APE1.Semantic proximity Read ↗

APE1 is dispensable for S-region cleavage but required for its repair in class switch recombination.Semantic proximity Read ↗

AID-initiated DNA lesions are differentially processed in distinct B cell populations.Semantic proximity Read ↗

Mismatch-mediated error prone repair at the immunoglobulin genes.Semantic proximity Read ↗

<i>Fam72a</i> controls the balance between error-prone and error-free DNA repair during antibody diversificationSemantic proximity Read ↗

Apex2 is required for efficient somatic hypermutation but not for class switch recombination of immunoglobulin genesSemantic proximity Read ↗

Fam72a enforces error-prone DNA repair during antibody diversification.Semantic proximity Read ↗

Somatic hypermutation: subverted DNA repair.Semantic proximity Read ↗

FAM72A antagonizes UNG2 to promote mutagenic uracil repair during antibody maturationSemantic proximity Read ↗

A broad atlas of somatic hypermutation allows prediction of activation-induced deaminase targets.Semantic proximity Read ↗

Uracil-DNA glycosylase in base excision repair and adaptive immunity: species differences between man and mouse.Semantic proximity Read ↗

Balancing AID and DNA repair during somatic hypermutation.Semantic proximity Read ↗

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