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Article

APE2 Promotes AID-Dependent Somatic Hypermutation in Primary B Cell Cultures That Is Suppressed by APE1.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jun 2023

Schrader Carol E, Williams Travis, Pechhold Klaus, Linehan Erin K, Tsuchimoto Daisuke, Nakabeppu Yusaku

Abstract excerpt

Somatic hypermutation (SHM) is necessary for Ab diversification and involves error-prone DNA repair of activation-induced cytidine deaminase-induced lesions in germinal center (GC) B cells but can also cause genomic instability. GC B cells express low levels of the DNA repair protein apurinic/apyrimidinic (AP) endonuclease (APE)1 and high levels of its homolog APE2. Reduced SHM in APE2-deficient mice suggests...

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Share to AICDA (Activation-Induced Cytidine Deaminase)
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37074207
DOI: 10.4049/jimmunol.2100946
PMCID: PMC10234595

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