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Article

APE1 is dispensable for S-region cleavage but required for its repair in class switch recombination.

Proceedings of the National Academy of Sciences of the United States of America - 2 Dec 2014

Xu Jianliang, Husain Afzal, Hu Wenjun, Honjo Tasuku, Kobayashi Maki

Abstract excerpt

Activation-induced cytidine deaminase (AID) is essential for antibody diversification, namely somatic hypermutation (SHM) and class switch recombination (CSR). The deficiency of apurinic/apyrimidinic endonuclease 1 (Ape1) in CH12F3-2A B cells reduces CSR to ∼20% of wild-type cells, whereas the effect of APE1 loss on SHM has not been examined. Here we show that, although APE1's endonuclease activity is important...

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Share to AICDA (Activation-Induced Cytidine Deaminase)
Share to Cytidine Deaminase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA-(Apurinic or Apyrimidinic Site) Lyase

Share to Immunoglobulin Class Switching

Share to Lymphoma, B-Cell

Share to MRE11 Homologue Protein

Share to Proto-Oncogene Proteins c-myc

Share to Somatic Hypermutation, Immunoglobulin

Source

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Identifiers

PMID: 25404348
DOI: 10.1073/pnas.1420221111
PMCID: PMC4260585

Genes

MRE11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

APE1 is dispensable for S-region cleavage but required for its repair in class switch recombination.PMID 25404348Read ↗

APE2 Promotes AID-Dependent Somatic Hypermutation in Primary B Cell Cultures That Is Suppressed by APE1.Semantic proximity Read ↗

Activation induced deaminase C-terminal domain links DNA breaks to end protection and repair during class switch recombinationSemantic proximity Read ↗

Apex2 is required for efficient somatic hypermutation but not for class switch recombination of immunoglobulin genesSemantic proximity Read ↗

Apurinic/Apyrimidinic Endonuclease 1 Is the Essential Nuclease during Immunoglobulin Class Switch RecombinationSemantic proximity Read ↗

Endonuclease G plays a role in immunoglobulin class switch DNA recombination by introducing double-strand breaks in switch regions.Semantic proximity Read ↗

AID in Antibody Diversification: There and Back Again.Semantic proximity Read ↗

Differential expression of APE1 and APE2 in germinal centers promotes error-prone repair and A:T mutations during somatic hypermutation.Semantic proximity Read ↗

AID- and Ung-dependent generation of staggered double-strand DNA breaks in immunoglobulin class switch DNA recombination: a post-cleavage role for AID.Semantic proximity Read ↗

REV7 is required for processing AID initiated DNA lesions in activated B cells.Semantic proximity Read ↗

Generating and repairing genetically programmed DNA breaks during immunoglobulin class switch recombinationSemantic proximity Read ↗

Transcription elongation factor ELOF1 is required for efficient somatic hypermutation and class switch recombinationSemantic proximity Read ↗

Depletion of recombination-specific cofactors by the C-terminal mutant of the activation-induced cytidine deaminase causes the dominant negative effect on class switch recombination.Semantic proximity Read ↗

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