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Article

AID-initiated DNA lesions are differentially processed in distinct B cell populations.

Journal of immunology (Baltimore, Md. : 1950) - 1 Dec 2014

Chen Zhangguo, Ranganath Sheila, Viboolsittiseri Sawanee S, Eder Maxwell D, Chen Xiaomi, Elos Mihret T, Yuan Shunzong, Yuan Shunzhong, Hansen Erica, Wang Jing H

Abstract excerpt

Activation-induced deaminase (AID) initiates U:G mismatches, causing point mutations or DNA double-stranded breaks at Ig loci. How AID-initiated lesions are prevented from inducing genome-wide damage remains elusive. A differential DNA repair mechanism might protect certain non-Ig loci such as c-myc from AID attack. However, determinants regulating such protective mechanisms are largely unknown. To test whether...

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Share to AICDA (Activation-Induced Cytidine Deaminase)
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Somatic Hypermutation, Immunoglobulin

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Identifiers

PMID: 25339658
DOI: 10.4049/jimmunol.1401549
PMCID: PMC4239163

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