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Article

Uracil-DNA glycosylase in base excision repair and adaptive immunity: species differences between man and mouse.

The Journal of biological chemistry - 13 May 2011

Doseth Berit, Visnes Torkild, Wallenius Anders, Ericsson Ida, Sarno Antonio, Pettersen Henrik Sahlin, Flatberg Arnar, Catterall Tara, Slupphaug Geir, Krokan Hans E, Kavli Bodil

Abstract excerpt

Genomic uracil is a DNA lesion but also an essential key intermediate in adaptive immunity. In B cells, activation-induced cytidine deaminase deaminates cytosine to uracil (U:G mispairs) in Ig genes to initiate antibody maturation. Uracil-DNA glycosylases (UDGs) such as uracil N-glycosylase (UNG), single strand-selective monofunctional uracil-DNA glycosylase 1 (SMUG1), and thymine-DNA glycosylase remove uracil...

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Share to DNA Repair
Share to Immunoglobulin Class Switching

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunoglobulins

Share to Mice, Inbred C57BL

Share to Mice, Transgenic

Share to Recombination, Genetic

Share to Species Specificity

Share to Uracil-DNA Glycosidase

Source

Open in PubMed Open full text

Identifiers

PMID: 21454529
DOI: 10.1074/jbc.M111.230052
PMCID: PMC3089509

Genes

SMUG1
UNG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

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Research trail→

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Uracil-DNA glycosylase in base excision repair and adaptive immunity: species differences between man and mouse.PMID 21454529Read ↗

SMUG1 is able to excise uracil from immunoglobulin genes: insight into mutation versus repair.Semantic proximity Read ↗

Uracil in DNA and its processing by different DNA glycosylasesSemantic proximity Read ↗

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Refining the Neuberger model: Uracil processing by activated B cells.Semantic proximity Read ↗

Uracil Accumulation and Mutagenesis Dominated by Cytosine Deamination in CpG Dinucleotides in Mice Lacking UNG and SMUG1.Semantic proximity Read ↗

Uracil–DNA glycosylase UNG1 isoform variant supports class switch recombination and repairs nuclear genomic uracilSemantic proximity Read ↗

Genomic Uracil Homeostasis during Normal B Cell Maturation and Loss of This Balance during B Cell Cancer DevelopmentSemantic proximity Read ↗

B cells from hyper-IgM patients carrying UNG mutations lack ability to remove uracil from ssDNA and have elevated genomic uracil.Semantic proximity Read ↗

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Differential expression of APE1 and APE2 in germinal centers promotes error-prone repair and A:T mutations during somatic hypermutation.Semantic proximity Read ↗

Activation-Induced Cytidine Deaminase-Dependent DNA Breaks in Class Switch Recombination Occur during G1 Phase of the Cell Cycle and Depend upon Mismatch RepairSemantic proximity Read ↗

High-fidelity correction of genomic uracil by human mismatch repair activities.Semantic proximity Read ↗

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