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Loss of endogenous tau suppresses APOE4-induced patterned behavioral decline and axon dysmorphia in a <i>C. elegans</i> model of Alzheimer’s disease

2025-05-11

Abstract excerpt

Alzheimer’s disease (AD) causes a characteristic spatiotemporal pattern of neurodegeneration. The factors that account for this pattern of degeneration are unclear. Previously, we generated a model of AD using the nematode Caenorhabditis elegans with the AD risk variant of apolipoprotein E, APOE4 . We showed that HSN class neurons degenerate in early adult animals. Here, we perform behavioral analyses to deduce...

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Literature Corpus work
6a693753-cb71-52a1-80e2-a126c282c18f
DOI
10.1101/2025.05.06.652574
Open publication

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Loss of endogenous tau suppresses APOE4-induced patterned behavioral decline and axon dysmorphia in a <i>C. elegans</i> model of Alzheimer’s diseaseDOI 10.1101/2025.05.06.652574
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