Article

Neuroprotective role of Hippo signaling by microtubule stability control in <i>C. elegans</i>

2024-03-13

Abstract excerpt

The evolutionarily conserved Hippo (Hpo) pathway has been shown to impact early development and tumorigenesis by governing cell proliferation and apoptosis. However, its post-developmental roles are relatively unexplored. Here, we demonstrate its roles in post-mitotic cells by showing that defective Hpo signaling accelerates age-associated structural and functional decline of neurons in C. elegans . Loss of wts-...

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Literature Corpus work: a52f1f68-be32-59d2-8aaa-98245867efdb
DOI: 10.1101/2024.03.11.584363

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