Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Loss of endogenous tau suppresses APOE4-induced patterned behavioral decline and axon dysmorphia in a model of Alzheimer's disease.

Disease models & mechanisms - 1 Jul 2026

Cardona Eric A, Webber Chelsea J, Wu Zheng, Bolton Blythe M, Sarinay-Cenik Elif, Pierce Jonathan T

Abstract excerpt

Alzheimer's disease (AD) causes a characteristic spatiotemporal pattern of neurodegeneration. The factors that account for this pattern of degeneration, including associated neuronal dysfunction and dysmorphia, are unclear. Previously, we generated a model of AD using the nematode Caenorhabditis elegans with the AD risk variant of apolipoprotein E (APOE4). We showed that the soma of HSN class neurons degenerate...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apolipoprotein E4
Share to Axons

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Behavior, Animal

Share to Caenorhabditis elegans

Share to Caenorhabditis elegans Proteins

Share to Microtubule-Associated Proteins

Share to Nerve Degeneration

Share to tau Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 42272336
DOI: 10.1242/dmm.052469
PMCID: PMC13474567

Genes

MAPT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Loss of endogenous tau suppresses APOE4-induced patterned behavioral decline and axon dysmorphia in a model of Alzheimer's disease.PMID 42272336Read ↗

Loss of endogenous tau suppresses APOE4-induced patterned behavioral decline and axon dysmorphia in a <i>C. elegans</i> model of Alzheimer’s diseaseSemantic proximity Read ↗

APP -Induced Patterned Neurodegeneration Is Exacerbated by APOE4 in Caenorhabditis elegansSemantic proximity Read ↗

<i>APP</i> -induced patterned neurodegeneration exacerbated by <i>APOE4</i> in <i>C. elegans</i>Semantic proximity Read ↗

Age-dependent accumulation of tau aggregation in Caenorhabditis elegansSemantic proximity Read ↗

Regulation of age-related structural integrity in neurons by protein with tau-like repeats (PTL-1) is cell autonomousSemantic proximity Read ↗

Functional Analysis of Late-Onset Alzheimer’s Disease Risk Genes in <i>Caenorhabditis elegans</i> Identifies Regulators of Neuronal AgingSemantic proximity Read ↗

Protein with tau-like repeats regulates neuronal integrity and lifespan in<i>C. elegans</i>Semantic proximity Read ↗

ApoE-associated modulation of neuroprotection from Aβ-mediated neurodegeneration in transgenic Caenorhabditis elegansSemantic proximity Read ↗

Use of Caenorhabditis elegans as a model to study Alzheimer’s disease and other neurodegenerative diseasesSemantic proximity Read ↗

Modeling Alzheimer’s Disease in Caenorhabditis elegansSemantic proximity Read ↗

Alzheimer’s disease-relevant tau modifications selectively impact neurodegeneration and mitophagy in a novel <i>C. elegans</i> single-copy transgenic modelSemantic proximity Read ↗

Levels of Amyloid Beta (Aβ) Expression in the Caenorhabditis elegans Neurons Influence the Onset and Severity of Neuronally Mediated Phenotypes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.