Article
Tau mutant A152T, a risk factor for FTD/PSP, induces neuronal dysfunction and reduced lifespan independently of aggregation in a C. elegans Tauopathy model.
Molecular neurodegeneration - 27 Apr 2016
Pir Ghulam Jeelani, Choudhary Bikash, Mandelkow Eckhard, Mandelkow Eva-Maria
Abstract excerpt
BACKGROUND: A certain number of mutations in the Microtubule-Associated Protein Tau (MAPT) gene have been identified in individuals with high risk to develop neurodegenerative diseases, collectively called tauopathies. The mutation A152TMAPT was recently identified in patients diagnosed with frontotemporal spectrum disorders, including Progressive Supranuclear Palsy (PSP), Frontotemporal Dementia (FTD),...
Topics
- Animals
- Animals, Genetically Modified
- Caenorhabditis elegans
- Humans
- Mutation
- Neurons
- Phenotype
- Risk Factors
- tau Proteins