Article
A genetic variant in osteoprotegerin is associated with progression of joint destruction in rheumatoid arthritis.
Arthritis research & therapy - 7 May 2014
Knevel Rachel, de Rooy Diederik P C, Saxne Tore, Lindqvist Elisabet, Leijsma Martha K, Daha Nina A, Koeleman Bobby P C, Tsonaka Roula, Houwing-Duistermaat Jeanine J, Schonkeren Joris J M, Toes Rene E M, Huizinga Tom W J, Brouwer Elisabeth, Wilson Anthony G, van der Helm-van Mil Annette H M
Abstract excerpt
INTRODUCTION: Progression of joint destruction in rheumatoid arthritis (RA) is partly heritably; 45 to 58% of the variance in joint destruction is estimated to be explained by genetic factors. The binding of RANKL (Receptor Activator for Nuclear Factor κ B Ligand) to RANK results in the activation of TRAF6 (tumor necrosis factor (TNF) receptor associated factor-6), and osteoclast formation ultimately leading to...
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