Article
Genetic studies on components of the Wnt signalling pathway and the severity of joint destruction in rheumatoid arthritis.
Annals of the rheumatic diseases - 1 May 2013
de Rooy Diederik P C, Yeremenko Nataliya G, Wilson Anthony Gerard, Knevel Rachel, Lindqvist Elisabet, Saxne Tore, Krabben Annemarie, Leijsma Martha K, Daha Nina A, Tsonaka S, Zhernakova A, Houwing-Duistermaat J J, Huizinga Tom W J, Toes René E M, Baeten Dominique L P, Brouwer E, van der Helm-van Mil Annette H M
Abstract excerpt
BACKGROUND: Progression of joint destruction in rheumatoid arthritis (RA) is partly heritable; knowledge of genetic factors may increase our understanding of the mechanisms underlying joint destruction. The activity of the Wnt/β-catenin pathway influences osteoblast differentiation. Dickkopf-1 (Dkk-1) and sclerostin (Sost) are negative regulators and lipoprotein receptor-related protein-5 (LRP-5) and Kremen-1 are...
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