Article
Osteoprotegerin Polymorphisms in a Mexican Population with Rheumatoid Arthritis and Generalized Osteoporosis: A Preliminary Report.
Journal of immunology research - 1 Jan 2015
Zavala-Cerna Maria Guadalupe, Moran-Moguel Maria Cristina, Cornejo-Toledo Jesus Alejandro, Gonzalez-Montoya Norma Guadalupe, Sanchez-Corona Jose, Salazar-Paramo Mario, Nava-Zavala Arnulfo Hernan, Aguilar-Chavez Erika Anita, Alcaraz-Lopez Miriam Fabiola, Gonzalez-Sanchez Alicia Guadalupe, Gonzalez-Lopez Laura, Gamez-Nava Jorge Ivan
Abstract excerpt
Bone disease in rheumatoid arthritis (RA) is a complex phenomenon where genetic risk factors have been partially evaluated. The system formed by receptor activator for nuclear factor-κB (RANK), receptor activator for nuclear factor-κB ligand (RANKL), and osteoprotegerin (OPG): RANK/RANKL/OPG is a crucial molecular pathway for coupling between osteoblasts and osteoclasts, since OPG is able to inhibit osteoclast...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
