Article
Genetic variants in IL15 associate with progression of joint destruction in rheumatoid arthritis: a multicohort study.
Annals of the rheumatic diseases - 1 Oct 2012
Knevel R, Krabben A, Brouwer E, Posthumus M D, Wilson A G, Lindqvist E, Saxne T, de Rooy D, Daha N, van der Linden M P M, Stoeken G, van Toorn L, Koeleman B, Tsonaka R, Zhernakoza A, Houwing-Duistermaat J J, Toes R, Huizinga T W J, van der Helm-van Mil A
Abstract excerpt
BACKGROUND: Interleukin (IL)-15 levels are increased in serum, synovium and bone marrow of patients with rheumatoid arthritis (RA). IL-15 influences both the innate and the adaptive immune response; its major role is activation and proliferation of T cells. There are also emerging data that IL-15 affects osteoclastogenesis. The authors investigated the association of genetic variants in IL15 with the rate of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.