Article
A genetic variant in granzyme B is associated with progression of joint destruction in rheumatoid arthritis.
Arthritis and rheumatism - 1 Mar 2013
Knevel R, Krabben A, Wilson A G, Brouwer E, Leijsma M K, Lindqvist E, de Rooy D P C, Daha N A, van der Linden M P M, Tsonaka S, Zhernakova A, Westra H-J, Franke L, Houwing-Duistermaat J J, Toes R E M, Huizinga T W J, Saxne T, van der Helm-van Mil A H M
Abstract excerpt
OBJECTIVE: Genetic factors account for an estimated 45-58% of the variance in joint destruction in rheumatoid arthritis (RA). The serine proteinase granzyme B induces target cell apoptosis, and several in vitro studies suggest that granzyme B is involved in apoptosis of chondrocytes. Serum levels of granzyme B are increased in RA and are also associated with radiographic erosions. The aim of this study was to...
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