Article
Genetic Factors for the Severity of ACPA-negative Rheumatoid Arthritis in 2 Cohorts of Early Disease: A Genome-wide Study.
The Journal of rheumatology - 1 Aug 2015
de Rooy Diederik P C, Tsonaka Roula, Andersson Maria L E, Forslind Kristina, Zhernakova Alexandra, Frank-Bertoncelj Mojca, de Kovel Caroline G F, Koeleman Bobby P C, van der Heijde Désirée M F M, Huizinga Tom W J, Toes René E M, Houwing-Duistermaat Jeanine J, Ospelt Caroline, Svensson Björn, van der Helm-van Mil Annette H M
Abstract excerpt
OBJECTIVE: Rheumatoid arthritis (RA) that is negative for anticitrullinated protein antibodies (ACPA) is a subentity of RA, characterized by less severe disease. At the individual level, however, considerable differences in the severity of joint destruction occur. We performed a study on genetic factors underlying the differences in joint destruction in ACPA-negative patients. METHODS: A genome-wide association...
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