Article
Association of a single-nucleotide polymorphism in CD40 with the rate of joint destruction in rheumatoid arthritis.
Arthritis and rheumatism - 1 Aug 2009
van der Linden Michael P M, Feitsma Anouk L, le Cessie Saskia, Kern Marlena, Olsson Lina M, Raychaudhuri Soumya, Begovich Ann B, Chang Monica, Catanese Joseph J, Kurreeman Fina A S, van Nies Jessica, van der Heijde Désirée M, Gregersen Peter K, Huizinga Tom W J, Toes René E M, van der Helm-Van Mil Annette H M
Abstract excerpt
OBJECTIVE: The severity of joint destruction in rheumatoid arthritis (RA) is highly variable from patient to patient and is influenced by genetic factors. Genome-wide association studies have enormously boosted the field of the genetics of RA susceptibility, but risk loci for RA severity remain poorly defined. A recent meta-analysis of genome-wide association studies identified 6 genetic regions for...
Topics
- Arthritis, Rheumatoid
- Arthrography
- CD40 Antigens
- Female
- Genetic Predisposition to Disease
- Health Status
- Humans
- Joints
- Male