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Article

MicroRNA-23b regulates cyclin-dependent kinase-activating kinase complex through cyclin H repression to modulate endothelial transcription and growth under flow.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jul 2014

Wang Kuei-Chun, Nguyen Phu, Weiss Anna, Yeh Yi-Ting, Chien Hou Su, Lee Alicia, Teng Dayu, Subramaniam Shankar, Li Yi-Shuan, Chien Shu

Abstract excerpt

OBJECTIVE: The site-specificity of endothelial phenotype is attributable to the local hemodynamic forces. The flow regulation of microRNAs in endothelial cells (ECs) plays a significant role in vascular homeostasis and diseases. The objective of this study was to elucidate the molecular mechanism by which the pulsatile shear flow-induced microRNA-23b (miR-23b) exerts antiproliferative effects on ECs. APPROACH AND...

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Source

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Identifiers

PMID: 24855060
DOI: 10.1161/ATVBAHA.114.303473
PMCID: PMC4119726

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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