Shear Difference: Flow Type Dictates Endothelial Flow-Responsive Gene Programs in a 3D-Printed in vitro Model

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Endothelial cells (ECs) are mechanosensitive and adopt distinct phenotypes in response to hemodynamic forces. These phenotypes are rarely seen in shear-responsive signalling studies because commonly used in vitro platforms rarely reproduce the true scale of vessel geometries or physiologic waveforms. <h4>Aim</h4> To determine how the presence and temporal pattern of flow im...

Topics

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• Base Sequence
• Biomechanical Phenomena
• Cells, Cultured
• DNA Primers
• Endothelium, Vascular
• Gene Expression Profiling
• Molecular Sequence Data
• Nucleic Acid Hybridization

Identifiers and source

Literature Corpus work

45509b72-44d9-54cd-8982-260380d8b210

DOI

10.1101/2025.11.24.690338