Article

Endothelial cell flow-mediated quiescence is temporally regulated and utilizes the cell cycle inhibitor p27

2023-06-11

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Endothelial cells regulate their cell cycle as blood vessels remodel and transition to quiescence downstream of blood flow-induced mechanotransduction. Laminar blood flow leads to quiescence, but how flow-mediated quiescence is established and maintained is poorly understood. <h4>Methods</h4> Primary human endothelial cells were exposed to laminar flow regimens and gene exp...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 45601c0e-fe94-5d09-a0cf-996dc382eb0a
DOI: 10.1101/2023.06.09.544403

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Endothelial cell flow-mediated quiescence is temporally regulated and utilizes the cell cycle inhibitor p27DOI 10.1101/2023.06.09.544403Read

Single-Cell RNA Sequencing Reveals Endothelial Cell Transcriptome Heterogeneity under Homeostatic Laminar FlowSemantic proximity Read

A requirement for Krüppel-Like Factor-4 in the maintenance of endothelial cell quiescenceSemantic proximity Read

Analysis of Endothelial-to-Haematopoietic Transition at the Single Cell Level identifies Cell Cycle Regulation as a Driver of DifferentiationSemantic proximity Read

Endothelial to mesenchymal transition: at the axis of cardiovascular health and diseaseSemantic proximity Read

Role of the cell cycle during human endothelial-to-haematopoietic transitionSemantic proximity Read

Endothelial cells on the move: dynamics in vascular morphogenesis and diseaseSemantic proximity Read

Lineage-enriched cell proliferation code underlies spatio-temporal regulation of cell cycle dynamics in lymphatic vesselsSemantic proximity Read

Fate and state transitions during human blood vessel organoid developmentSemantic proximity Read

cSTAR analysis identifies endothelial cell cycle as a key regulator of flow-dependent artery remodelingSemantic proximity Read

Silencing <i>KRIT1</i> Partially Reverses the Effects of Disturbed Flow on the Endothelial Cell TranscriptomeSemantic proximity Read

Vascular Regulation of Hematopoietic Stem Cell Homeostasis, Regeneration, and AgingSemantic proximity Read

Human vein-to-artery endothelial cell fate transition is driven by VEGF/ERK activation and PI3K inhibitionSemantic proximity Read