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Endothelial fluid shear stress sensing in vascular health and disease

29 Feb 2016

Abstract excerpt

Endothelial cells transduce the frictional force from blood flow (fluid shear stress) into biochemical signals that regulate gene expression and cell behavior via specialized mechanisms and pathways. These pathways shape the vascular system during development and during postnatal and adult life to optimize flow to tissues. The same pathways also contribute to atherosclerosis and vascular malformations. This...

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PMID: 26928035
DOI: 10.1172/jci83083

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